The Roles of Piezoelectric Ultrasonic Motors in Industry 4.0 Era: Opportunities & Challenges

Piezoelectric Ultrasonic motors (USM) are based on the principle of converse piezoelectric effect i.e., vibrations occur when an electrical field is applied to piezoelectric materials. USMs have been studied several decades for their advantages over traditional electromagnetic motors. Despite having many advantages, they have several challenges too. Recently many researchers have started focusing on Industry 4.0 or Fourth Industrial revolution phase of the industry which mostly emphasis on digitization & interconnection of the entities throughout the life cycle of the product in an industrial network to get the best possible output. Industry 4.0 utilizes various advanced tools for carrying out the nexus between the entities & bringing up them on digital platform. The studies of the role of USMs in Industry 4.0 scenario has never been done till now & this article fills that gap by analyzing the piezoelectric ultrasonic motors in depth & breadth in the background of Industry 4.0. This article delivers the novel working principle, illustrates examples for effective utilization of USMs, so that it can buttress the growth of Industry 4.0 Era & on the other hand it also analyses the key Industry 4.0 enabling technologies to improve the performance of the USMs

Engineering Metabolism of Chimeric Antigen Receptor (CAR) Cells for Developing Efficient Immunotherapies

Chimeric antigen receptor (CAR) T cell-based therapies have shown tremendous advancement in clinical and pre-clinical studies for the treatment of hematological malignancies, such as the refractory of pre-B cell acute lymphoblastic leukemia (B-ALL), chronic lymphocytic leukemia (CLL), and large B cell lymphoma (LBCL). However, CAR T cell therapy for solid tumors has not been successful clinically. Although, some research efforts, such as combining CARs with immune checkpoint inhibitor-based therapy, have been used to expand the application of CAR T cells for the treatment of solid tumors. Importantly, further understanding of the coordination of nutrient and energy supplies needed for CAR T cell expansion and function, especially in the tumor microenvironment (TME), is greatly needed. In addition to CAR T cells, there is great interest in utilizing other types of CAR immune cells, such as CAR NK and CAR macrophages that can infiltrate solid tumors. However, the metabolic competition in the TME between cancer cells and immune cells remains a challenge. Bioengineering technologies, such as metabolic engineering, can make a substantial contribution when developing CAR cells to have an ability to overcome nutrient-paucity in the solid TME. This review introduces technologies that have been used to generate metabolically fit CAR-immune cells as a treatment for hematological malignancies and solid tumors, and briefly discusses the challenges to treat solid tumors with CAR-immune cells